Edward J Bastyr Selected Research

ruboxistaurin

4/2015	Effect of ruboxistaurin on albuminuria and estimated GFR in people with diabetic peripheral neuropathy: results from a randomized trial.
10/2007	Factors that impact symptomatic diabetic peripheral neuropathy in placebo-administered patients from two 1-year clinical trials.
4/2007	A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy.
8/2005	Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial.

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Edward J Bastyr Research Topics

Disease

8	Type 2 Diabetes Mellitus (MODY) 01/2018 - 04/2007
7	Peripheral Nervous System Diseases (PNS Diseases) 04/2015 - 08/2005
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2018 - 11/2016
2	Disease Progression 10/2007 - 10/2007
2	Hypesthesia (Numbness) 09/2007 - 08/2005
2	Diabetes Mellitus 08/2005 - 08/2005
1	Non-alcoholic Fatty Liver Disease 01/2018
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018
1	Body Weight (Weight, Body) 08/2017
1	Hyperglycemia 08/2017
1	Albuminuria 04/2015
1	Hypoglycemia (Reactive Hypoglycemia) 01/2014
1	Diabetic Neuropathies (Diabetic Neuropathy) 04/2007
1	Dyspepsia (Indigestion) 11/2006
1	Drug-Related Side Effects and Adverse Reactions 11/2006
1	Hyperalgesia 08/2005
1	Pain (Aches) 08/2005

Drug/Important Bio-Agent (IBA)

6	NAD (NADH)IBA 10/2007 - 08/2005
4	Insulin (Novolin)FDA Link 01/2018 - 01/2014
4	Insulin Glargine (Lantus)FDA Link 01/2018 - 01/2014
4	ruboxistaurinIBA 04/2015 - 08/2005
2	InsulinsIBA 01/2018 - 11/2016
2	basal insulin peglisproIBA 01/2018 - 08/2015
2	Protein Kinase C betaIBA 04/2007 - 08/2005
1	Blood Glucose (Blood Sugar)IBA 01/2018
1	Hemoglobins (Hemoglobin)IBA 01/2018
1	Keratin-18 (Keratin 18)IBA 01/2018
1	IncretinsIBA 08/2017
1	Glucagon-Like Peptide 1 (GLP 1)IBA 08/2017
1	Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)IBA 08/2017
1	Glucagon-Like Peptide-1 ReceptorIBA 08/2017
1	Metformin (Glucophage)FDA LinkGeneric 08/2017
1	LipidsIBA 11/2016
1	Insulin Lispro (Humalog)FDA Link 08/2015
1	Glucose (Dextrose)FDA LinkGeneric 01/2014
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2014
1	Long-Acting Insulin (Insulin, Long Acting)FDA Link 01/2014
1	LY2605541IBA 01/2014
1	Protein Kinase CIBA 04/2007
1	Creatine Kinase (Creatine Phosphokinase)IBA 11/2006
1	Mesylates (Mesylate)IBA 08/2005

Therapy/Procedure

4	Therapeutics 11/2016 - 08/2005
2	Glycemic Control 08/2017 - 10/2007